The immunological characteristics of central and peripheral immune organs (such as bone marrow, thymus, lymph nodes, spleen, etc.) are quite different from those of high-risk tissues and organs (such as liver, intestinal tract, lung, brain, etc.). Due to their unique structure, physiological function and tissue microenvironment, these tissues and organs may contain specific or unique cell subpopulations and functional molecules, thus forming regional immune characteristics. The regional immune characteristics are related to the occurrence and development of many diseases related to the tissues and organs May be closely related. Due to the lack of research on the regional immune characteristics of disease-prone tissues and organs, there is still a lack of comprehensive and in-depth understanding of the body's immune function and its physiological and pathological significance, which has affected the development of immunity and disease research and disease immune control to a certain extent. In order to further explain the immunopathological mechanism of diseases and promote the research of translational medicine, there is an urgent need to conduct basic, cutting-edge and systematic pilot research on the regional immune characteristics of tissues and organs to reveal the internal relationship between regional immune characteristics and major diseases and find new Target of immunotherapy, and put forward new strategies for disease prevention and treatment.
This major research program aims to combine major basic research in immunology (regional immunological characteristics) with major national needs (major disease prevention and treatment). Focusing on the research of “regional immune characteristics and diseases of tissues and organs”, by comparing with immune organs, we focus on studying the regional immune characteristics of tissues and organs with high incidence of important diseases (such as liver, intestine, lung, brain, kidney, joints, etc.) The basic traits of immune cell subsets unique to these tissues and organs, reveal the basic properties of regional immune characteristics, discover the cellular regulatory networks and molecular regulatory networks that form the regional immune characteristics of tissues and organs, and deeply study the pathophysiological mechanisms of related diseases to reveal regional immunity The intrinsic connection between characteristics and major diseases, looking for new immunotherapy targets and ways.
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